姓名: 王璐

学科: 遗传学

职称/人才类别: 副研究员，硕士生导师

电话：0871-65033362

电子邮件: wanglu@#ynu.edu.cn

个人简历：

2000年9月-2004年7月：山东大学，生命科学学院，理学学士

2004年9月-2010年12月：中科院上海植物生理生态研究所，国家基因研究中心，硕博连读，获博士学位，导师韩斌。

2011年3月-2017年12月：云南大学/云南生物资源保护与利用国家重点实验室，动物遗传多样性与进化团队，助理研究员。

2017年5月：入选云南大学“东陆中青年骨干教师培养计划”。

2017年12月至今：云南大学/云南生物资源保护与利用国家重点实验室，动物遗传多样性与进化团队，副研究员。

2018年5月至今：云南大学/云南生物资源保护与利用国家重点实验室，硕士生导师

2018年12月：入选云南省万人计划青年拔尖人才培养计划

个人简介：

主持国家自然科学基金项目两项，参与多项，作为骨干参与973计划一项，负责横向项目2项。指导（含协助指导）研究生已毕业1名博士研究生，6名硕士研究生，在读6名硕士研究生。招收遗传学专业以及生物工程专业（遗传方向）的学生。

主要研究方向

1）进化基因组学；

2）家养动物群体遗传学；

3）家犬驯化及复杂性状进化的遗传基础。

已发表期刊论文：

Shao-jie Zhang#, Guo-Dong Wang#, Pengcheng Ma#, Liang-liang Zhang, Ting-Ting Yin, Yan-hu Liu, Newton O. Otecko, Meng Wang, Ya-ping Ma, Lu Wang, Bingyu Mao*, Peter Savolainen*, Ya-ping Zhang*. Genomic regions under selection in the feralization of the dingoes. Nature Communications, 2020, 11(1):671. (2020IF=12.121, 2020IF5Y=13.61)（收录情况：SCI，综合性期刊1区（综合性期刊1区））

Shilong Yang#, Yunfei Wang#, Lu Wang#, Peter Kamau, Hao Zhang, Anna Luo, Xiancui Lu, Ren Lai*. Target switch of centipede toxins for antagonistic switch . Science Advances, 2020, 6(32):eabb5734. (2020IF=13.116, 2020IF5Y=14.094)（收录情况：SCI，综合性期刊1区（综合性期刊1区））

Limin Zhao#, Hao Ke#, Haibo Xu, Guo-Dong Wang, Honglei Zhang, Li Zou, Shu Xiang, Mengyuan Li, Li Peng, Mingfang Zhou, Lingling Li, Lei Ao, Qin Yang, Che-Kun James Shen, Ping Yi*, Lu Wang*, Baowei Jiao*. TDP-43 Facilitates Milk Lipid Secretion by Post-Transcriptional Regulation of Btn1a1 and Xdh. Nature Communications, 2020, 11(1):341. (2020IF=12.121, 2020IF5Y=13.61)（收录情况：SCI，综合性期刊1区（综合性期刊1区））

Guo-Dong Wang#, Xiu-Juan Shao#, Bing Bai#, Junlong Wang, Xiaobo Wang, Xue Cao, Yan-Hu Liu, Xuan Wang, Ting-Ting Yin, Shao-Jie Zhang, Yan Lu, Zechong Wang, Lu Wang, Wenming Zhao, Bing Zhang, Jue Ruan∗, Ya-Ping Zhang∗. Structural variation during dog domestication: insights from gray wolf and dhole genomes. National Science Review, 2019, 6(1):110-122. (2019IF=13.222, 2019IF5Y=13.833)（收录情况：SCI，综合性期刊1区，CSCD，CSTPCD）

Guo-Dong Wang#, Ming Zhang#, Xuan Wang, Melinda A. Yang, Peng Cao, Feng Liu, Heng Lu, Xiaotian Feng, Pontus Skoglund, Lu Wang, Qiaomei Fu*, Ya-Ping Zhang*. Genomic approaches reveal an endemic subpopulation of gray wolves in southern China. iScience, 2019, 20:110-118. (2019IF=0, 2019IF5Y=0)（收录情况：SCI将收录）

Yan-Hu Liu#, Lu Wang #, Tao Xu#, Xiaomin Guo, Yang Li, Ting-Ting Yin, He-Chuan Yang, Yang Hu, Adeniyi C. Adeola, Oscar J. Sanke, Newton O. Otecko, Meng Wang, Ya-Ping Ma, Olaogun S. Charles, Mikkel-Holger S. Sinding, Shyam Gopalakrishnan, José Alfredo Samaniego, Anders J. Hansen, Carlos Fernandes，Philippe Gaubert, Jane Budd, Philip M. Dawuda, Eli Knispel Rueness, Lubin Jiang, Weiwei Zhai, M.T.P Gilbert, Min-Sheng Peng, Xiaopeng Qi*, Guo-Dong Wang*, Ya-Ping Zhang*. 2018. Whole-genome sequencing of African dogs provides insights into adaptations against tropical parasites. Molecular Biology and Evolution 35(2):287-298. (IF2018=14.479，生物I区)

张少杰，王国栋，王璐*。2018。家犬的前世今生。生物学通报 53(1):1-3. 【Zhang Shaojie, Wang Guodong, Wang Lu*. 2018. Past and present life of dogs. Bulletin of Biology 53(1):1-3.】（封面，北大核心）

Lu Wang #, Ya-Ping Ma#, Qi-Jun Zhou, Ya-Ping Zhang, Peter Savolainen, Guo-Dong Wang*. 2017. The geographical distribution of grey wolves (Canis lupus) in China: a systematic review. Zoological Research, 2016, 37(6): 315-326.

Hong Wu#, Yan-Hu Liu#, Guo-Dong Wang, Chun-Tao Yang, Newton O. Otecko, Fei Liu, Shi-Fang Wu, Lu Wang *, Li Yu*, Ya-Ping Zhang*. 2016. Identifying molecular signatures of hypoxia adaptation from sex chromosomes: a case for Tibetan Mastiff based on analyses of X chromosome. Scientific Reports 6:35004. (IF2016=5.228)

Li Yu*#, Guo-Dong Wang#, Jue Ruan#, Yong-Bin Chen#, Cui-Ping Yang#, Xue Cao#, Hong Wu#, Yan-Hu Liu#, Zheng-Lin Du#, Xiao-Ping Wang#, Jing Yang#, Shao-Chen Cheng#, Li Zhong, Lu Wang, Xuan Wang, Jing-Yang Hu, Lu Fang, Bing Bai, Kai-Le Wang, Na Yuan, Shi-Fang Wu,  Bao-Guo Li, Jin-Guo Zhang, Ye-Qin Yang, Cheng-Lin Zhang, Yong-Cheng Long, Hai-Shu Li, Jing-Yuan Yang, David M Irwin, Oliver A Ryder, Ying Li, Chung-I Wu*, Ya-Ping Zhang*. 2016. Genomic analysis of snub-nosed monkeys (Rhinopithecus) identifies genes and processes related to high-altitude adaptation. Nature Genetics 48(8):947-952. (IF2016=31.616)

Guo-Dong Wang#, Weiwei Zhai#, He-Chuan Yang#, Lu Wang#, Li Zhong, Yan-Hu Liu, Ruo-Xi Fan, Ting-Ting Yin, Chun-Ling Zhu, Andrei D Poyarkov, David M Irwin, Marjo K Hytönen, Hannes Lohi, Chung-I Wu, Peter Savolainen*, Ya-Ping Zhang*. 2016. Out of southern East Asia: the natural history of domestic dogs across the world. Cell Research 26(1):21-33. (IF2016=14.812)

Shaojun Liu*#, Jing Luo#, Jing Chai#, Li Ren#, Yi Zhou#, Feng Huang#, Xiaochuan Liu#, Yubao Chen, Chun Zhang, Min Tao, Bin Lu, Wei Zhou, Guoliang Lin, Chao Mai, Shuo Yuan, Jun Wang, Tao Li, Qinbo Qin, Hao Feng, Kaikun Luo, Jun Xiao, Huan Zhong, Rurong Zhao, Wei Duan, Zhenyan Song, Yanqin Wang, Jing Wang, Li Zhong, Lu Wang, Zhaoli Ding, Zhenglin Du, Xuemei Lu, Yun Gao, Robert W. Murphy, Yun Liu, Axel Meyer*, Ya-Ping Zhang*. 2016. Genomic incompatibilities in the diploid and tetraploid offspring of the goldfish × common carp cross. Proceedings of the National Academy of Sciences of the United States of America (PNAS) 113(5):1327-1332. (IF2016= 9.423)

柳延虎，王璐*，于黎*。2015。单分子实时测序技术的原理与应用。遗传 36(3):259-268. 【Yanhu Liu, Lu Wang*, Li Yu*. 2015. The principle and application of the single-molecule real-time sequencing technology. Hereditas (Beijing) 36(3):259-268.】

Bing Bai#, Wen-Ming Zhao#, Bi-Xia Tang#, Yan-Qing Wang, Lu Wang, Zhang Zhang, He-Chuan Yang, Yan-Hu Liu, Jun-Wei Zhu, David M. Irwin, Guo-Dong Wang*, Ya-Ping Zhang*. 2015. DoGSD: the dog and wolf genome SNP database. Nucleic Acids Research 43(Database issue):D777-D783. (IF2015=9.112)

尹婷婷，王璐，王国栋*。2015。传染性肿瘤研究进展。遗传 37(11):1086-1094.【Tingting Yin, Lu Wang, Guodong Wang*. 2015. Recent advances in transmissible tumors. Hereditas(Beijing) 37(11):1086-1094.】

Guo-Dong Wang#, Ruo-Xi Fan#, Weiwei Zhai，Fei Liu, Lu Wang, Li Zhong, Hong Wu, He-Chuan Yang, Shi-Fang Wu, Chun-Ling Zhu, Yan Li, Yun Gao, Ri-Li Ge, Chung-I Wu, Ya-Ping Zhang*. 2014. Genetic Convergence in the Adaptation of Dogs and Humans to the High-Altitude Environment of the Tibetan Plateau. Genome Biology Evolution 6(8):2122-2128. (IF2014=4.532)

Xue Cao, David M. Irwin, Yan-Hu Liu, Lu-Guang Cheng, Lu Wang, Guo-Dong Wang*, Ya-Ping Zhang*. 2014. Balancing Selection on CDH2 May Be Related to the Behavioral Features of the Belgian Malinois. PLoS ONE 9(10):e110075. (IF2014=3.534)

Guo-dong Wang#, Weiwei Zhai#, He-chuan Yang, Ruo-xi Fan, Xue Cao, Li Zhong, Lu Wang, Fei Liu, Hong Wu, Lu-guang Cheng, Andrei D. Poyarkov, Nikolai A. Poyarkov JR, Shu-sheng Tang, Wen-ming Zhao, Yun Gao, Xue-mei Lv, David M. Irwin, Peter Savolainen, Chung-I Wu*, Ya-ping Zhang*. 2013. The genomics of selection in dogs and the parallel evolution between dogs and humans. Nature Communication 4:1860. (IF2013=10.015)

Lu Wang#, Ahong Wang#, Xuehui Huang, Qiang Zhao, Guojun Dong, Qian Qian, Tao Sang, Bin Han*. 2011. Mapping 49 quantitative trait loci at high resolution through sequencing-based genotyping of rice recombinant inbred lines. Theoretical and Applied Genetics 122(2):327-340. (IF2017=4.132)

Xuehui Huang#, Xinghua Wei#, Tao Sang#, Qiang Zhao#, Qi Feng#, Yan Zhao, Canyang Li, Chuanrang Zhu, Tingting Lu, Zhiwu Zhang, Meng Li, Danlin Fan, Yunli Guo, Ahong Wang, Lu Wang, Liuwei Deng, Wenjun Li, Yiqi Lu, Qijun Weng, Kunyan Liu, Tao Huang, Taoying Zhou, Yufeng Jing, Wei Li, Zhang Lin, Edward S Buckler, Qian Qian, Qi-Fa Zhang, Jiayang Li, Bin Han*. 2010. Genome-wide association studies of 14 agronomic traits in rice landraces. Nature Genetics 42(11):961-967. (IF2017=27.959)

Xuehui Huang#, Qi Feng#, Qian Qian#, Qiang Zhao#, Lu Wang#, Ahong Wang#, Jianping Guan, Danlin Fan, Qijun Weng, Tao Huang, Guojun Dong, Tao Sang, Bin Han*. 2009. High-throughput genotyping by whole-genome resequencing. Genome Research 19(6):1068-1076. (IF2017=11.992)

主持科研项目：

1.       国家自然科学基金，地区项目；基于系统发育基因组学方法构建果蝇科主干类群进化关系（31760617；39万（直接经费）；2018.1-2021.12；主持

2.       国家自然科学基金，青年项目；家犬驯化中与攻击性行为相关的人工选择研究（31201712）；23万；2013.1-2015.12；主持

3.       国家重点基础研究计划（973计划），子课题；家犬性状进化的遗传和基因组基础（013CB835202）；296万（到云南大学96万）；2013.01-2017.08；参与单位负责人

4.       大麻种质基因组重测序，云南省农科院，18万，2014.10-2015.10；主持

5.       Illumina高通量测序与分析，东莞博奥木华基因科技有限公司，49.22万，2015.07-2018.07；主要负责人

获奖及人才：

1.       2018年12月，入选云南省万人计划青年拔尖人才培养计划

2.     2017.5，入选云南大学东陆中青年骨干教师培养计划

3.       2017.1，中国精品科技期刊顶尖学术论文“F5000”， 中国科学技术信息研究所，排名二

4.       2016.11，《遗传》2015年度优秀论文，《遗传》编辑部，排名二